In brief The discovery of penicillin nearly 100 years ago started a gold rush to find new antimicrobials. Scientists mined microscopic bacteria and fungi for compounds that could help fight off infection. But over time the rate of antimicrobial discoveries slowed to a crawl. Now, modern-day bioprospectors are using genomics, synthetic biology, and AI to dig deeper than they ever have before. A new golden age of antibiotics may be upon us, say some on the hunt, though getting a drug candidate int...