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A near-autonomous AI chemist improves a challenging reaction in medicinal chemistry

OpenAI’s work in science is motivated by a simple belief: advanced AI can become a powerful partner for scientists, helping them explore more ideas, connect distant concepts, design better experiments, and accelerate discoveries that benefit humanity. We have already shared early examples of models contributing to novel results in mathematics, including work on the unit distance problem⁠, in theoretical physics, through a new result on gluon amplitudes⁠, and in biology, where GPT‑5 helped lower ...

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