CASE REPORT articleFront. Neurosci., 28 May 2026 Sec. NeuropharmacologyVolume 20 - 2026 | https://doi.org/10.3389/fnins.2026.1813281AbstractBackground: Advanced Alzheimer’s disease (AD) is generally regarded as a stage of irreversible functional decline. Psilocybin is known to transiently alter large-scale brain network dynamics and to induce plasticity-related mechanisms in preclinical models, yet clinical data in advanced dementia remain lacking.Case presentation: We report the case of an octo...