MainElectrical synapses enable the direct flow of ions and small molecules between two cells and play a prominent part in coupling electrical activity in multiple organs, including the brain2,3,4. Electrical synapses comprise multiple gap junction channels, each composed of two docked hemichannels embedded in the membranes of two touching cells. Each hemichannel is an oligomer that consists of six monomeric proteins called connexins, of which there are 21 isoforms in humans5,6. Most connexins ca...