At OpenAI, we believe that AI can meaningfully accelerate life science innovation. To test this belief, we collaborated with the Applied AI team at Retro Bio⁠(opens in a new window), a longevity biotech startup, to create and research the impact of GPT‑4b micro, a miniature version of GPT‑4o specialized for protein engineering.In vitro, these redesigned proteins achieved greater than a 50-fold higher expression of stem cell reprogramming markers than wild-type controls. They also demonstrated en...